Initially the company covered only the one route, but in the 1950s it added a route to Villahermosa. Other cities served today include Cancún, Oaxaca, Campeche, Cuautla, Huatulco, Mérida and Coatzacoalcos. In Mexico City A.D.O. serves the T.A.P.O. (Terminal de Pasajeros de Oriente) station.

A.D.O.'s motto since 1939 has been Siempre primera (Always first), because it has always used the most modern buses possible, such as the DINA Avante, the DINA Olímpico and the DINA Flexible "Jorobado". At the present time the line uses Mercedes Benz, Volvo or Busscar buses, painted silver with a red wave the length of the bus containing the letters "ADO" in white.

A.D.O. GL (Gran Linea) is the executive class (luxury) service of A.D.O. The company also runs Autotour, a charter bus service, and Multipack, a package express service.

This article is a free translation of the article in the Spanish Wikipedia, with some additional information.